SAND-1 (Mon1a (490aa) and Mon1b (547aa)) and CCZ-1 (Ccz1) are new factors for the apoptotic cells removal. Impaired apoptotic cell clearance (due to defective recognition, internalization or degradation) results in autoimmune disease. Mon1a and Mon1b, are similarly required for phagosome matuRation. Mon1a and Mon1b are required for phagosome matuRation. Mona and its partner CCZ-1 form a complex (but not either protein alone) could bind small GTPase Rab7, thus influence Rab7 activation; Mon1a, Mon1b and CCZ-1 are critical and evolutionarily conserved components regulating the processing of ingested apoptotic cell corpses.
应用类型
Enzyme-linked immunosorbent assay|Flow cytometry|Immunohistochemistry|Immunoprecipitation|Western blot
免疫原
A synthetic peptide derived from a portion of the intra domain 510-547aa of human Mon1b protein. This sequence is identical to human, mouse, rat, bovine and chicken.
来源宿主
Rabbit
反应性
该Anti-Mon1b/SAND2 Polyclonal 抗体的反应性请参考该产品的说明书
保存建议
The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
其他
Aviva Systems Biology总部位于加利福尼亚州圣迭戈，在中国北京设有办公室，专注于为研究需求提供多克隆和单克隆抗体、ELISA试剂盒、蛋白质和定制服务。Aviva Systems Biology生产了24,000种经过验证的多克隆抗体，并提供近20,000种ELISA试剂盒，定制实验室服务包括蛋白表达和纯化、抗体开发，以及ELISA的开发、验证和生产。Aviva Systems Biology为与独特物种和靶标相关的研究提供独特工具，研究领域包括转录因子、癌症、心血管、细胞生物学、DNA损伤和修复、表观遗传学、信号转导、细胞分化、干细胞生物学等等。
