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中文名称

Anti-IFN gamma PerCP-Cy 5.5(流式抗体)

英文名字
Anti-IFN gamma PerCP-Cy 5.5
供应商
EXBIO
产品货号
T9-706-T025
产品报价
¥已停产
产品说明书
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产品新闻
背景资料
The Interferon gamma (IFN-gamma; 16-25 kDa) is an important regulator of the immune response, produced in activated Th1 cells and NK cells, particularly in response to IL-2, TNF-alpha and IL-12; its production is suppressed by IL-4, IL-10, and TGF-beta. The producing of IFN-gamma is activated by specific antigens or mitogens through the T cell antigen receptor. IFN-gamma polypeptide forms: 40-60 kDa forms are observable under non-denaturing conditions as dimers and trimers; 20 kDa and 25 kDa forms exist due to variable glycosylation. IFN-gamma belongs to the type II interferons, also called immune IFN. IFN-gamma shows antiviral activity and has important immunoregulatory functions. It is a potent activator of macrophages and had antiproliferative effects on transformed cells. IFN-gamma plays an important role in regulating B cell differentiation by simultaneously stimulating class switch recombination to the IgG3 and IgG2a isotypes while represing class switch recombination to the IgE and IgG1 isotypes. It also appears to promote antigen presentation by B cells through its effects on MHC. Binding of IFN-gamma to its receptor increases the expression of class I MHC on all somatic cells. It also enhances the expression of class II MHC on antigen-presenting cells. IFN-gamma is the major means by which T cells activate macrophages, increasing their ability to kill bacteria, parasites, and tumours. The activation of macrophages by IFN-gamma is essential for the elimination of bacteria that replicate within the phagosomes of macrophages (f.e. Mycobacteria and Listeria monocytogenes). IFN-gamma can potentiate the high antiviral and antitumor effects of the type I interferons (IFN-alpha, IFN-beta). IFN-gamma may also activate neutrophils and NK cells.
应用类型
FC (QC tested)
免疫原
Interferon gamma derived from human leukocytes
来源宿主
小鼠
反应性
Non-human primates, Human
保存建议
Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
其他
EXBIO是捷克一家著名的生物试剂公司,专注于流式细胞术配套试剂的开发。自1990年成立以来,EXBIO公司研发和制造的抗体分销全球。目前,EXBIO可提供超过4000种质优、价廉的研究和临床应用抗体,涵盖了血液学,免疫学,癌症,干细胞和细胞生物学等领域,如:CD分子、细胞粘附分子、细胞骨架、凋亡、细胞信号传导、肿瘤标志物、人血型、HLA、生殖等研究用抗体,涉及荧光染料如FITC、PE、PE-Cy5、PE-Cy7、APC、PerCP、PerCP-Cy5.5、Pacific Blue、Pacific Orange、Alexa Fluor 488、Alexa Fluor 647、Alexa Fluor 700、Biotin等多达13种,满足客户各类实验需求。
注意
该页面的中文产品信息的翻译,仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前,请浏览说明书确认。
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