该CASP9 Polyclonal Antibody. Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
应用类型
WB,IHC-p,IF,ELISA
免疫原
Synthesized peptide derived from human Caspase-9 around the non-phosphorylation site of Thr125.
