TAGLN3 holds a putative Actin-binding domain， two potential phosphorylation sites， two EF-hand motifs and a calponin-homology （CH） domain. TAGLN3 is homologic to transgelin and calponin， two cytoskeleton-interacting proteins. TAGLN3 is a member of the calponin family， and is co-localized with Actin and tubulin， which indicates that TAGLN3 has a part in neuronal plasticity or as a signaling protein. As a result of a wide-ranging expression pattern， TAGLN3 is able to take different roles in the developing and adult brain.
