MSH6 deficiency result in hereditary non-polyposis colorectal cancer （Lynch syndrome）. HNPCC is an autosomal， dominantly inherited disease linked with rise in cancer susceptibility. MSH6 is is known by its familial predisposition to premature onset colorectal carcinoma （crc） and extra-colonic cancers of the gastrointestinal， urological and female reproductive tracts.
MSH6 is involved in repairing DNA. MSH6 protein repairs mistakes that occure during DNA replication in preparation for cell division. The MSH6 protein bonds with MSH2 protein and form an active protein complex which recognizes specific parts on the DNA where mistakes have been made during DNA replication. MLH1-PMS2 protein complex， afterwards takes over with the repair. MSH6 gene is part of the set of the mismatch repair （MMR） genes.
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大肠杆菌中重组表达
溶解建议
Sterile Filtered clear solution. MSH6 is supplied in 50mM Tris-Acetate， pH-7.5， 1mM EDTA and 20% Glycerol.
保存建议
Store at 4℃ if entire vial will be used within 2-4 weeks.
Store， frozen at -20℃ for longer periods of time.
Please avoid freeze thaw cycles.
