The signal sequence receptor （SSR） is a glycosylated endoplasmic reticulum membrane receptor related with protein translocation across the ER membrane. The SSR consists of 2 subunits， a 34-kD glycoprotein （alpha-SSR or SSR1） and a 22-kD glycoprotein （beta-SSR or SSR2）. The human beta-signal sequence receptor gene （SSR2） maps to chromosome bands 1q21-q23. Diseases correlated with SSR2 include calcaneonavicular coalition， and osteosarcoma， and among its related super-pathways are Viral mRNA Translation and Generic Transcription Pathway.
