TBCEL， is a factor that is in charge of the microtubule cytoskeleton in determining cell behavior. TBCEL plays a role as a regulator of tubulin stability. While widely expressed in testis， TBCEL is also present in several tissues at a much lower level. TBCEL comprises of seven LRR （leucine-rich） repeats， one LRRCT domain and one ubiquitin-like domain. The gene that translates TBCEL consists of 66，704 bases and maps to human chromosome 11q23.3. Chromosome 11 houses over 1，400 genes and consist of nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome， Jacobsen syndrome， Niemann-Pick disease， hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that map to chromosome 11.
