The A-kinase anchor proteins (AKAPs) are a group ofnstructurally diverse proteins, which have the common function ofnbinding to the regulatory subunit of protein kinase A (PKA) andnconfining the holoenzyme to discrete locations within the cell.nThis gene encodes a member of the AKAP family. The encoded proteinnbinds to the RII-beta regulatory subunit of PKA, and also tonprotein kinase C and the phosphatase calcineurin. It isnpredominantly expressed in cerebral cortex and may anchor the PKAnprotein at postsynaptic densities (PSD) and be involved in thenregulation of postsynaptic events. It is also expressed in Tnlymphocytes and may function to inhibit interleukin-2 transcriptionnby disrupting calcineurin-dependent dephosphorylation of NFAT.
应用类型
WB
免疫原
This AKAP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-143 amino acids from the Central region of human AKAP5.
