This gene encodes the beta subunit of the glycinenreceptor, which is a pentamer composed of alpha and beta subunits.nThe receptor functions as a neurotransmitter-gated ion channel,nwhich produces hyperpolarization via increased chloride conductancendue to the binding of glycine to the receptor. Mutations in thisngene cause startle disease, also known as hereditary hyperekplexianor congenital stiff-person syndrome, a disease characterized bynmuscular rigidity. Alternative splicing results in multiplentranscript variants.
应用类型
WB
免疫原
This GLRB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-132 amino acids from the N-terminal region of human GLRB.
