Lymphokine-activated killer T-cell-originated protein kinase （PBK） is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase （MAPKK） family. PBK is abundant in placenta （is also found in the testis’ outer cell layer of seminiferous tubules） and absent from adult brain tissue. PBK is involved in the activation of lymphoid cells and supports testicular functions， with a possible role in the process of spermatogenesis. Mitotic phosphorylation is required for PBK’s catalytic activity. Once phosphorylated，PBK forms a complex with TP53， leading to TP53 destabilization and weakening of G2/M checkpoint during doxorubicin-induced DNA damage. PBK is active only during mitosis. In addition， a PDZ domain in the tumor suppressor protein Dlg can coordinate with the T/SXV motif of PBK. PBK also phosphorylates MAP kinase p38， and may have a role in the activation of lymphoid cells.
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大肠杆菌中重组表达.
溶解建议
提供的重组人PDZ连接激酶产品形式为无菌的澄清溶液.
保存建议
建议将重组人PDZ连接激酶产品整瓶保存于4℃可保存2-4周. 长期保存，请置于-20℃.长期保存，推荐添加载体蛋白 （0.1% HSA or BSA）.请避免反复冻融.
