Adrenomedullin (ADM), a vasodilator produced by most contractile cells, isncharacterized by persistent hypotensive activity. ADM is involved in thenregulation of fluid and electrolyte homeostasis and the maintenance ofncardiovascular functioning, and in hypertensive patients, the level of ADMnin plasma is upregulated. Natriuresis is a common systemic manifestation ofnaneurysmal subarachnoid hemorrhage. ADM has strong natriuretic actions andnADM-induced natriuresis is caused by an increase in glomerular filtration ratenand a decrease in distal tubular sodium reabsorption. ADM is present both innthe periphery and brain, and this peptide can exert central effects such asndecreasing food ingestion.
应用类型
WB
免疫原
Synthetic peptide, corresponding to amino acids 116-160 of Human ADM
