P450 enzymes constitute a family of monooxygenase enzymes that are involved in the metabolism of a wide array of endogenous and xenobiotic compounds. There are currently 57 known active cytochrome P450 (CYP) genes and 58 known pseudogenes present in the human genome. Several P450 enzymes have been classified by sequence similarities as members of the CYP1A and CYP2A subfamilies. CYP2W1 is a 490 amino acid protein that belongs to the CYP2 family of cytochrome P450 proteins. These proteins are usually involved in the metabolism of foreign compounds. CYP2W1 metabolizes arachidonic acid and catalyzes the oxidation of indole. CP2W1 represents a tumor-specific P450 isoform that is universally conserved in vertebrates and is a potential drug target in cancer therapeutics.
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P450 enzymes constitute a family of monooxygenase enzymes that are involved in the metabolism of a wide array of endogenous and xenobiotic compounds. There are currently 57 known active cytochrome P450 (CYP) genes and 58 known pseudogenes present in the human genome. Several P450 enzymes have been classified by sequence similarities as members of the CYP1A and CYP2A subfamilies. CYP2W1 is a 490 amino acid protein that belongs to the CYP2 family of cytochrome P450 proteins. These proteins are usually involved in the metabolism of foreign compounds. CYP2W1 metabolizes arachidonic acid and catalyzes the oxidation of indole. CP2W1 represents a tumor-specific P450 isoform that is universally conserved in vertebrates and is a potential drug target in cancer therapeutics.
