Rabbit monoclonal to APP-Rabbit monoclonal to APP代理/参数/厂家-一抗-艾美捷科技有限公司

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背景资料: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis, Involved in cell mobility and transcription regulation through protein-protein interactions, Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb, Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP, Inhibits G(o) alpha ATPase activity (By similarity), Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1, Involved in copper homeostasis/oxidative stress through copper ion reduction, In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation, Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV, The splice isoforms that contain the BPTI domain possess protease inhibitor activity, Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons, Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1.

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