- 中文名称
Rabbit polyclonal to CTCF
- 英文名字
- Rabbit polyclonal to CTCF
- 供应商
- Nordic BioSite
- 产品货号
- NDC-ASJ-58ED5D
- 产品报价
- ￥询价/100ul
- 产品说明书
- 点击查看
- 购买方式
- 90%产品中国有现货库存。银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- Chromatin binding factor that binds to DNA sequence specific sites, Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers, Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene, Also binds to the PLK and PIM1 promoters, Acts as a transcriptional activator of APP, Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression, Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription, Seems to act as tumor suppressor, Plays a critical role in the epigenetic regulation, Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus, On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2, Plays a critical role in gene silencing over considerable distances in the genome, Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones, Inversely, binding to target sites is prevented by CpG methylation, Plays a important role in chromatin remodeling, Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping, Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory, Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription, When bound to chromatin, it provides an anchor point for nucleosomes positioning, Seems to be essential for homologous X-chromosome pairing, May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation, May play a role in preventing the propagation of stable methylation at the escape genes from X- inactivation, Involved in sister chromatid cohesion, Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites, Regulates asynchronous replication of IGF2/H19, Plays a role in the recruitment of CENPE to the pericentromeric/centromeric regions of the chromosome during mitosis.
- 应用类型
- WB,IHC,IP,ChIP
- 免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human CTCF (NP_006556.1).
- 来源宿主
- rabbit
- 反应性
- human,mouse,rat
- 保存建议
- Store at -20℃. Avoid freeze / thaw cycles.
- 其他
- Nordic BioSite(北欧生物) 总部位于瑞典，成立于1997年，旨在分销研究和诊断领域的高质量和创新产品。 Nordic BioSite 被公认为整个北欧生物医学研究和诊断产品领域的领导者。他们拥有超过570万种的产品组合，代理了遍布欧洲和美国的顶级生物试剂制造商，是欧洲知名的一站式生物试剂代理商。除了作为分销商之外，Nordic BioSite 还拥有不断增长的自产产品线——BioSite mAb、BioSite ELISA、BioSite Flow、Optibodies和 BioSite Protein, 目前艾美捷代理的是Nordic BioSite自产产品线(共26W+产品)。Nordic BioSite的产品类型主要是抗体，蛋白和试剂盒，产品适用范围涵盖15个不同的物种(人，牛，犬，鲶鱼，鸡，海豚，马，猫，豚鼠，小鼠，绵羊，兔子，大鼠，猪和火鸡)，可为您提供一站式的生命科学研究解决方案~
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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