- 中文名称
Mouse monoclonal to APEX1
- 英文名字
- Mouse monoclonal to APEX1
- 供应商
- Nordic BioSite
- 产品货号
- NDC-ASJ-4C15A4
- 产品报价
- ￥询价/100ul
- 产品说明书
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- 购买方式
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- 产品新闻
- 背景资料
- Multifunctional protein that plays a central role in the cellular response to oxidative stress, The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors, Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents, Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends, Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules, Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER, Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks, May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation, Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB, Plays a role in the protection from granzymes-mediated cellular repair leading to cell death, Also involved in the DNA cleavage step of class switch recombination (CSR), On the other hand, APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR, Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs), Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression, Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance, Acts also as an endoribonuclease involved in the control of single-stranded RNA metabolism, Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD), In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression, Associates, together with YBX1, on the MDR1 promoter, Together with NPM1, associates with rRNA, Binds DNA and RNA.
- 应用类型
- WB,IHC,IF
- 免疫原
- A synthetic peptide of human APEX1
- 来源宿主
- mouse
- 反应性
- human
- 保存建议
- Store at 4℃. Avoid freeze / thaw cycles.
- 其他
- Nordic BioSite(北欧生物) 总部位于瑞典，成立于1997年，旨在分销研究和诊断领域的高质量和创新产品。 Nordic BioSite 被公认为整个北欧生物医学研究和诊断产品领域的领导者。他们拥有超过570万种的产品组合，代理了遍布欧洲和美国的顶级生物试剂制造商，是欧洲知名的一站式生物试剂代理商。除了作为分销商之外，Nordic BioSite 还拥有不断增长的自产产品线——BioSite mAb、BioSite ELISA、BioSite Flow、Optibodies和 BioSite Protein, 目前艾美捷代理的是Nordic BioSite自产产品线(共26W+产品)。Nordic BioSite的产品类型主要是抗体，蛋白和试剂盒，产品适用范围涵盖15个不同的物种(人，牛，犬，鲶鱼，鸡，海豚，马，猫，豚鼠，小鼠，绵羊，兔子，大鼠，猪和火鸡)，可为您提供一站式的生命科学研究解决方案~
- 注意
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