- 中文名称
CHEK2的兔多克隆抗体
- 英文名字
- Rabbit polyclonal to CHEK2
- 供应商
- Nordic BioSite
- 产品货号
- NDC-ASJ-3E5D76
- 产品报价
- ￥询价/100ul
- 产品说明书
- 点击查看
- 购买方式
- 90%产品中国有现货库存。银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks, May also negatively regulate cell cycle progression during unperturbed cell cycles, Following activation, phosphorylates numerous effectors preferentially at the consensus sequence , Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity, Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression, May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest, Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination, Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1, Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML, Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53, Phosphorylation of MDM4 may also reduce degradation of p53/TP53, Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1, Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1, Its absence may be a cause of the chromosomal instability observed in some cancer cells, Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition.
- 应用类型
- WB,IHC,IF,FC
- 免疫原
- A synthetic peptide of human CHEK2
- 来源宿主
- rabbit
- 反应性
- human
- 保存建议
- Store at 4℃. Avoid freeze / thaw cycles.
- 其他
- Nordic BioSite(北欧生物) 总部位于瑞典，成立于1997年，旨在分销研究和诊断领域的高质量和创新产品。 Nordic BioSite 被公认为整个北欧生物医学研究和诊断产品领域的领导者。他们拥有超过570万种的产品组合，代理了遍布欧洲和美国的顶级生物试剂制造商，是欧洲知名的一站式生物试剂代理商。除了作为分销商之外，Nordic BioSite 还拥有不断增长的自产产品线——BioSite mAb、BioSite ELISA、BioSite Flow、Optibodies和 BioSite Protein, 目前艾美捷代理的是Nordic BioSite自产产品线(共26W+产品)。Nordic BioSite的产品类型主要是抗体，蛋白和试剂盒，产品适用范围涵盖15个不同的物种(人，牛，犬，鲶鱼，鸡，海豚，马，猫，豚鼠，小鼠，绵羊，兔子，大鼠，猪和火鸡)，可为您提供一站式的生命科学研究解决方案~
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
-
