Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.
应用类型
该Mouse Monoclonal Antibody to SDHB产品的应用类型详情查看产品说明书。
免疫原
Purified recombinant fragment of human SDHB (AA: 29-280) expressed in E. Coli.
