CD11b (integrin alphaM subunit) is a 165-170 kDa type I transmembrane glycoprotein that non-covalently associates with integrin beta2 subunit (CD18); expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component.
应用类型
FC
免疫原
Rheumatoid synovial cells and human monocytes.
来源宿主
该Rabbit IgG polyclonal antibody for C-C chemokine receptor type 9(CCR9) detection. Tested with WB in Human.产品的来源宿主详情查看产品说明书。
