Prostaglandin-H2 D-isomerase（PTGDS) is a glutathione-independent prostaglandin D synthase which catalyzes the conversion of prostaglandin H2（PGH2) to postaglandin D2（PGD2). PTGDS is may have vital roles in both maturation and maintenance of the central nervous system and male reproductive system. PTGDS is the most abundant protein in the cerebral spinal fluid and recent evidence suggests that PTGDS acts as a beta-amyloid chaperone and may play a role in the deposition of Ab plaques in Alzheimer’s disease.
