Select-HA 50 k是一种透明质酸（HA）制剂，采用重组多杀性巴氏杆菌透明质酸合酶通过体外合成制备，粒径分布均匀且窄。Select-HA 50 k和Select-HATM是Hyalose LLC的商标。背景透明质酸（HA）是一种高分子量的阴离子多糖（1 000-10 000 kD），由重复的二糖组成，是结缔组织细胞外基质的几种糖胺聚糖组分之一。游离HA被肝脏吸收，在肝脏中被降解和回收。数据表明HA水平之间的关系，局部炎症和严重程度的许多疾病，如肝炎B或C类风湿性关节炎肝纤维化等。储存-20 °C或以下。建议避免频繁冻融等分。避免微生物或HA降解酶的污染。Jing W. DeAngelis P. L. 单分散透明质酸聚合物的同步化学酶促合成。J Biol Chem 2004 279（40）42345-9.
产品描述
Select-HA 50k is a hyaluronic acid (HA) preparation of uniform and narrow size distribution prepared by in vitro synthesis using recombinant Pasteurella multocida hyaluronan synthase. Select-HA 50k and Select-HA™ is a trademark of Hyalose LLC.BackgroundHyaluronic acid (HA) is a high molecular weight anionic polysaccharide (1 000-10 000 kD) composed of repeating disaccharides and is one of several glycosaminoglycan components of the extracellular matrix of connective tissue. Free HA is taken up by the liver where it is degraded and recycled. Data indicates a relationship between HA levels local inflammation and severity of many disease such as hepatitis B or C rheumatoid arthritis liver fibrosis etc.Storage-20 °C or below. Avoid frequent freeze-thaw aliquoting is recommended. Avoid contamination with microbes or HA-degrading enzymes.References1. Jing W.; DeAngelis P. L. Synchronized chemoenzymatic synthesis of monodisperse hyaluronan polymers. J Biol Chem 2004 279 (40) 42345-9.
