MAL-dPEG®-Lys(-5(6)-羧基荧光素)-NH-m-dPEG®-NH-m-MAL-dPEG®₄-Lys(-5(6)-Carboxyfluorescein)-NH-m-dPEG®₂₄-5 mg代理/参数/厂家-生化试剂-艾美捷科技有限公司

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中文名称: MAL-dPEG®-Lys(-5(6)-羧基荧光素)-NH-m-dPEG®-NH-m

英文名字: MAL-dPEG®₄-Lys(-5(6)-Carboxyfluorescein)-NH-m-dPEG®₂₄-5 mg

供应商: Click Chemistry Tools

产品货号: CCT-QBD-11577-5

产品报价: ￥询价/5mg

产品说明书: 点击查看

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产品新闻

背景资料: MAL-dPEG®4-Lys(5(6)-羧基荧光素)-NH-m-dPEG®24，产品编号QBD-11577，是Vector Laboratories独特的专利模块化、可设计的有效载荷递送试剂之一，称为Sidewinder™。 Sidewinder™产品构建在离散PEG(dPEG®)主链上，用于抗体-药物缀合物(ADC)和相关构建体。有效载荷(细胞毒素，染料，小分子)装载到链的侧臂上。远端的甲氧基封端的dPEG®24间隔基保护有效载荷并改变性能。nMAL-dPEG®4-Lys(5(6)-羧基荧光素)-NH-m-dPEG®24(产品编号QBD-11577)的马来酰亚胺反应性基团通过硫醇-马来酰亚胺反应(迈克尔加成反应)与生物分子上的游离硫醇反应。侧臂用5(6)-羧基荧光素(ex/em = 493/517)官能化，并可用于追踪细胞运输和缀合分子如抗体或抗体片段的内化。nSidewinder™产品旨在帮助创建稳定的高DAR ADC。已发表的研究表明，将疏水有效载荷(例如，细胞毒素)靠近抗体表面并用SuperHydrophilic™ dPEG®构建体保护它，通过许多功效测量比将有效载荷置于接头的远端更好。该分子还可用于修饰和优化BD、细胞运输和内化、血清半衰期和免疫原性。“

产品描述: MAL-dPEG®4-Lys(5(6)-carboxyfluorescein)-NH-m-dPEG®24, product number QBD-11577, is one of Vector Laboratories' unique, patented class of modular, designable payload delivery reagents called Sidewinder™. Sidewinder™ products are built on a discrete PEG (dPEG®) backbone for use in antibody-drug conjugates (ADCs) and related constructs. The payload (cytotoxin, dye, small molecule) loads onto the chain's sidearm. The distal end's methoxy-terminated dPEG®24 spacer protects payloads and modifies performance.nThe maleimide reactive group of MAL-dPEG®4-Lys(5(6)-carboxyfluorescein)-NH-m-dPEG®24, product number QBD-11577 reacts with free thiols on the biomolecule through the thiol-maleimide reaction (a Michael addition reaction). The sidearm is functionalized with 5(6)-carboxyfluorescein (ex/em = 493/517) and can be used to track cell trafficking and internalization of a conjugated molecule such as an antibody or antibody fragment.nSidewinder™ products are designed to facilitate the creation of stable, high-DAR ADCs. Published research has shown that putting a hydrophobic payload (e.g., a cytotoxin) close to the antibody surface and protecting it with a SuperHydrophilic™ dPEG® construct is better by many measures of efficacy than putting the payload at the distal end of the linker. This molecule can also be used to modify and optimize BD, cell trafficking and internalization, serum half-life, and immunogenicity.nThe dPEG® linkers and spacers in the Sidewinder™ construct are uniform, single molecular-weight PEGs with discrete chain lengths. This differs from traditional, non-uniform polymer PEG linkers and spacers, which have a dispersed range of PEG chain lengths, each with a unique molecular weight. In contrast to dispersed polymer PEGs, dPEG® products are high-purity compounds with reproducible purity profiles.nSidewinder™ molecules are also fully designable. MAL-dPEG®4-Lys(5(6)-carboxyfluorescein)-NH-m-dPEG®24 can be modified to change the spacer lengths, add more sidearm attachment points, add different sidearm attachment points to carry payloads with different reactivities, change the maleimide attachment group to a different reactive group, and many more customizations. Please inquire about your specific needs.

产品形式: 黄色至深黄色固体

保存建议

其他: Click Chemistry Tools（CCT）公司位于美国亚利桑那州斯科茨代尔（Scottsdale,AZ）。自公司成立以来，一致致力于不断开发和扩展一系列连接产品。他们利用特别新的研究成果研发生产出新颖的交联和标记试剂。产品被广泛用于药物研发、癌症治疗以及各类诊断技术等。此外，CCT还可以提供个性化的定制产品，已满足不同用户的需求。目前CCT的产品线主要包括：Azides（Biotin-Azides）试剂、Bis-sulfone交联试剂、DBCO试剂、TCO试剂、Terminal Alkyne试剂、Tetrazine试剂、标记试剂盒以及分选用底物等。nFluoroprobes公司位于美国亚利桑那州斯科茨代尔(Scottsdale, AZ)，自成立以来，一直致力于不断开发一系列的连接(linker)产品。利用特别新的研究成果研发生产出各类新颖的交联和标记试剂。其产品被广泛用于药物研发与筛选、疾病治疗方法和诊断技术等领域。此外，Fluoroprobes还可以根据客户的个性化需求提供各类定制连接产品。代表产品有Classic Fluorescent Dyes, AZDye, Cyanine Dyes, IR Dyes, MB dyes以及一些标记试剂盒等。nQuanta Biodesign公司位于美国中部的俄亥俄州，成立于1997年。也是专注于生产研发各类标记产品的品牌之一。其研发的产品与dPEG技术相结合，生产出他们独有的专利产品dPEG Building Blocks and Linkers，被广泛用于细胞治疗和分子诊断等研究领域。另外，还可为广大科研工作者提供多种化学修饰试剂以及传统Liner等。n目前上述三个品牌都已被被Vectorlabs收购并整合到Vectorlabs产品中