中文名称

Lipoamido-dPEG

英文名字

Lipoamido-dPEG®₄-TFP ester-1000 mg

供应商

Click Chemistry Tools

产品货号

CCT-QBD-10641-1000

产品报价

￥询价/1000mg

产品说明书

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购买方式

银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系。本公司所有产品仅供科研使用，不用于临床诊断。

产品新闻

背景资料

Lipoamido-dPEG®4-TFP酯(产品编号QBD-10641)是金和银表面(例如纳米颗粒上)的单分子量离散PEG(dPEG®)改性剂。在24个原子长的dPEG®间隔基的一端上的硫辛酸部分与金属如金和银形成配价键。TFP酯与游离胺反应以形成游离胺，最佳在pH 7.5 - 8.0范围内。从硫辛酸环中的二硫键到与2，3，5，6-四氟苯酚(TFP)酯相邻的羰基碳的距离为24个原子(28.0个)。该产品的应用包括在金属表面上形成自组装单分子层(SAM)，以及将肽和蛋白质交联和固定到金属纳米颗粒表面。

产品描述

Lipoamido-dPEG®4-TFP ester, product number QBD-10641, is a single molecular weight, discrete PEG (dPEG®) modifier of gold and silver surfaces, for example, on nanoparticles. The lipoic acid moiety on one end of the 24-atoms-long dPEG® spacer forms dative bonds with metals like gold and silver. The TFP ester reacts with free amines to form free amines, optimally in the pH range 7.5 - 8.0. The distance from the disulfide bond in the lipoic acid ring to the carbonyl carbon adjacent to the 2,3,5,6-tetrafluorophenol (TFP) ester, the distance is 24 atoms (28.0 Å). Applications for this product include creating self-assembled monolayers (SAMs) on metal surfaces and crosslinking and immobilizing peptides and proteins to the surfaces of metal nanoparticles.nLipoic acid, also known as alpha-lipoic acid, a-lipoic acid, and thioctic acid, consists of a five-membered ring containing a disulfide attached to a pentanoic acid group. As a naturally occurring antioxidant, lipoic acid functions as a cofactor in several enzyme systems. It is a bidentate thiol ligand that forms two stable dative bonds per lipoic acid group with gold, silver, and other metals. These dative bonds form with oxidized lipoic acid or reduced dihydrolipoic acid (DHLA). Because it forms two dative bonds on metal surfaces, lipoic acid is more stable than PEGylation reagents containing a single thiol. This increased stability prevents lipoic-acid-functionalized dPEG® products from being oxidized off the metal surface. The lipoic acid group forms dative bonds with metals with or without reduction to DHLA. If reduction to DHLA is preferred, Tris(2-carboxyethyl)phosphine (TCEP) will rapidly reduce lipoic acid to DHLA.nTFP esters react more readily with amines and possess better hydrolytic stability than N-hydroxysuccinimide (NHS). The superiority of PEG-TFP esters over NHS esters is documented in the scientific literature.nWhen using this product, it is typical to conjugate the carboxyl end of the dPEG® to an amine to form an amide bond before forming a dative bond between a metal surface and the lipoic acid moiety of Lipoamido-dPEG®4-TFP ester. The TFP ester reacts optimally at pH 7.5 – 8.0, but it will also react with amines at pH values above and below this range.nLipoamido-dPEG®4-TFP ester has limited solubility in water or aqueous buffer. We recommend using dry (over 3 Å molecular sieves) water-miscible solvents such as N, N-dimethylacetamide (DMAC) or acetonitrile to form a stock solution that can be added to aqueous buffer to carry out the reaction.

产品形式

淡黄色至琥珀色粘稠液体

保存建议

其他

Click Chemistry Tools（CCT）公司位于美国亚利桑那州斯科茨代尔（Scottsdale,AZ）。自公司成立以来，一致致力于不断开发和扩展一系列连接产品。他们利用特别新的研究成果研发生产出新颖的交联和标记试剂。产品被广泛用于药物研发、癌症治疗以及各类诊断技术等。此外，CCT还可以提供个性化的定制产品，已满足不同用户的需求。目前CCT的产品线主要包括：Azides（Biotin-Azides）试剂、Bis-sulfone交联试剂、DBCO试剂、TCO试剂、Terminal Alkyne试剂、Tetrazine试剂、标记试剂盒以及分选用底物等。nFluoroprobes公司位于美国亚利桑那州斯科茨代尔(Scottsdale, AZ)，自成立以来，一直致力于不断开发一系列的连接(linker)产品。利用特别新的研究成果研发生产出各类新颖的交联和标记试剂。其产品被广泛用于药物研发与筛选、疾病治疗方法和诊断技术等领域。此外，Fluoroprobes还可以根据客户的个性化需求提供各类定制连接产品。代表产品有Classic Fluorescent Dyes, AZDye, Cyanine Dyes, IR Dyes, MB dyes以及一些标记试剂盒等。nQuanta Biodesign公司位于美国中部的俄亥俄州，成立于1997年。也是专注于生产研发各类标记产品的品牌之一。其研发的产品与dPEG技术相结合，生产出他们独有的专利产品dPEG Building Blocks and Linkers，被广泛用于细胞治疗和分子诊断等研究领域。另外，还可为广大科研工作者提供多种化学修饰试剂以及传统Liner等。n目前上述三个品牌都已被被Vectorlabs收购并整合到Vectorlabs产品中

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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