Tolperisone is a centrally acting muscle relaxant (muscle relaxant acting on spasticity by interaction with upper motor neurons), which is also used for the treatment of chronic pain. It is mainly used for treating muscle spasticities of neurological origin and painful muscle spasms due to rheumatologic conditions. Besides being an effective antispastic agent, tolperisone also has analgesic activity in rodents6 and in humans7. It possesses relatively few side effects in humans.
产品描述
A Non-Selective Nav Channel Blocker
产品形式
Voltage-gated Na+ channels (VGSC, Nav) are critically important for electrogenesis and nerve impulse conduction. Certain Na+ channel isoforms are predominantly expressed in peripheral sensory neurons associated with pain sensation, and the expression and functional properties of Nav in peripheral sensory neurons can be dynamically regulated following axonal injury or peripheral inflammation.
