Pandinotoxin Kα (PiTx-Kα) is a 35 amino acid peptidyl toxin isolated from the Pandinus imperator (Emperor scorpion) venom. It is a highly potent and selective blocker of voltage-activated K+ channels. PiTx-Kα preferentially blocks rapidly inactivating (A-type) K+ channels. In general, channel inhibitors can be pore blockers or gating modifiers. Pore blockers bind to the channel in 1:1 stoichiometry and plug the pore of the channel impeding the flow of the ionic current. These toxins are small proteins that block the passage of K+ ions by binding at the pore entryway on the extracellular side of the channel, thereby inhibiting the ion flux. The interactions of toxins with K+ channels are among the strongest and most specific known in protein-protein complexes.
产品描述
A Selective Blocker of A-type and Shaker-Related Voltage-Gated K+ Channels
产品形式
Scorpion venoms are a rich source of ion channel modulators. The scorpion toxins have been useful molecules in probing the K+ channel structures and functions.
保存建议
艾美捷为您提供的Alonmone Labs原装进口的Pandinotoxin KAlpha (5 X 50 µg)产品可室温运输，建议您在收到产品后将其置于合适的温度下保存。
