ω-Conotoxin FVIA is originally isolated from Conus Fulmen. It is a selective, potent and reversible voltage-gated N-Type Ca2+ (CaV2.2) channel blocker that preferentially blocks nociception in inflammatory pain models, and allodynia and hyperalgesia in neuropathic pain models1,2. Studies have shown that ω-Conotoxin FVIA demonstrates analgesic potency and greater reversibility for the treatment of refractory pain and low side effects