Native ω-Agatoxin IVA was originally isolated from Agelenopsis aperta spider venom, and was shown to be a selective blocker of CaV2.1 (P/Q type) channels. However, the sensitivity depends on the auxiliary b subunit isoform2 and on the splice variant. Therefore, the effective concentration varies between systems. In accordance, the toxin blocks presynaptic Ca2+ currents and synaptic transmission in a variety of synapses.
产品描述
A Blocker of P/Q-Type CaV Channels
产品形式
Native ω-Agatoxin IVA was originally isolated from Agelenopsis aperta spider venom, and was shown to be a selective blocker of CaV2.1 (P/Q type) channels. However, the sensitivity depends on the auxiliary b subunit isoform2 and on the splice variant. Therefore, the effective concentration varies between systems. In accordance, the toxin blocks presynaptic Ca2+ currents and synaptic transmission in a variety of synapses.