SB-705498 is a specific and potent antagonist for TRPV1. Generally, TRPV1 inhibitors are classified as either both capsaicin and proton blockers, and mainly capsaicin blockers. SB-705498 belongs to the first class. After experimenting with lesser potent and effective antagonists, the major advantageous modification the compound's developers had introduced into the related TRPV1 archetypal inhibitors was a trifluoromethyl-substituted pyridine ring; it presented SB-705498 with good solubility and oral bioavailability, superior pharmacokinetic properties.
产品描述
An Antagonist of TRPV1 Channels
产品形式
SB-705498 is a specific and potent antagonist for TRPV1. Generally, TRPV1 inhibitors are classified as either both capsaicin and proton blockers, and mainly capsaicin blockers. SB-705498 belongs to the first class. After experimenting with lesser potent and effective antagonists, the major advantageous modification the compound's developers had introduced into the related TRPV1 archetypal inhibitors was a trifluoromethyl-substituted pyridine ring; it presented SB-705498 with good solubility and oral bioavailability, superior pharmacokinetic properties.
