Penfluridol is not subtype-selective on the three neuronal T-type Ca+2 channels. The potency of DPBPs as T-type Ca+2 channel antagonists parallels their potency as D2 receptor antagonists.nBlock of other channels has not been studied in detail, although it should be noted that these drugs are also potent blockers of K+ channels and bind with subnanomolar affinity to L-type channels.
产品描述
A T-Type Ca2+ Channel Blocker and D2 Receptor Antagonist
产品形式
Penfluridol was first synthesized in 1968, it is a white micro-crystalline tertiary amine, only slightly soluble in water. Penfluridol is a member of the potent and long-acting series of diphenylbutyl piperidine (DPBPs) neuroleptics of which pimozide is the prototype. This drug is an effective long acting neuroleptic, particularly useful in the maintenance therapy of schizophrenic patients.
