Lorcainide is an acetanilide derivative which blocks Nav channels. It possesses both local anesthetic and antiarrhythmic properties and in experimental animals it elevates the ventricular fibrillation threshold and protects against ouabain-induced arrhythmias. Clinically, it is gaining an important place in the therapy of recurrent premature ventricular contractions, recurrent ventricular tachycardia and repetitive atrial tachycardias.
产品描述
A Local Anesthetic and Antiarrythmic, NaV Channel Blocker
产品形式
Voltage-gated sodium channels (VGSC, Nav) are critically important for electrogenesis and nerve impulse conduction. Certain sodium channel isoforms are predominantly expressed in peripheral sensory neurons associated with pain sensation, and the expression and functional properties of Nav in peripheral sensory neurons can be dynamically regulated following axonal injury or peripheral inflammation.
