中文名称

伊拉地平（50毫克）

英文名字

Isradipine

供应商

Alomone

产品货号

ALO-I-100-50

产品报价

￥已停产

产品说明书

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产品新闻

背景资料

Isradipine is a dihydropyridine that acts as a L-type, voltage-gated Ca2+ channel blocker and is used in the clinic to treat hypertension. Isradipine inhibits L-type channels expressed in Xenopus oocytes with IC50 = 0.2 µM at a holding potential of -80 mV and the inhibition is state dependent and increases with reduced membrane hyperpolarization. Slow excitatory synaptic currents in dopaminergic neurons in slices of rat substantia nigra pars compacta and ventral tegmental area, which were evoked by a train of focally delivered electrical stimuli, were depressed by isradipine (30 nM-100 µM) in a concentration-dependent and reversible manner. In addition, isradipine, was shown recently to be a putative effective treatment for Parkinson’s disease, by affecting particularly the excitability of certain CaV1.3 expressing dopaminergic neurons. In a pancreatic cell line, insulin secretion triggered by 16.7 mM glucose, was completely abolished by 5 µM isradipine.

产品描述

A Potent Blocker of L-Type (both CaV1.2 and CaV1.3) Ca+ Channels

产品形式

L-type (CaV1), voltage-gated Ca2+ channels are plasma membrane protein complexes which allow the passage of Ca2+ ions into cells following depolarization of the membrane potential. L-type channels are widely expressed in cardiac and smooth muscle where they control contraction and therefore were recognized as a therapeutic target for cardiovascular diseases.

保存建议

艾美捷为您提供的Alonmone Labs原装进口的Isradipine (50 mg)产品可室温运输，建议您在收到产品后将其置于合适的温度下保存。

其他

Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证，以冻干粉形式提供，可确保产品生物活性和保质期。Alomone可提供多种包装规格，灵活方便。作为Alomone Labs在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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