Hexamethonium is a depolarising ganglionic blocker of nicotinic nACh (NN) receptor that acts in autonomic ganglia by binding mostly in or on the NN receptor, and not the acetylcholine binding site itself. It does not have any effect on mAChR located on target organs of the parasympathetic nervous system.
产品描述
A Blocker of nAChRs
产品形式
Acetylcholine, released by cholinergic neurons, activates two groups of acetylcholine receptors (AChRs); muscarinic AChRs (mAChRs) which belong to the superfamily of G-protein coupled receptors (GPCRs) and nicotinic AChRs (nAChRs) which belong to the ligand-gated ion channel superfamily. nAChRs also respond to nicotine, hence their name.