Glibenclamide is a member of the sulfonylurea class of drugs, an anti-diabetic that inhibits KATP channels in pancreatic β-cells, leading to increased insulin release. Sulfonylurea drugs work by inhibiting sulfonylurea receptor 1 (SUR1). In addition this drug acts as aTRPA1 agonist and demonstrates pleiotropic protective effects in acute CNS injury. Glibenclamide activates human TRPA1 in a concentration range that is commonly used to inhibit KATP channels in vitro. It has an EC50 value isof 48 nM at pH 7.4.
产品描述
An Activator of TRPA1 Channel and a Blocker of KATP Channels
产品形式
Glibenclamide is a member of the sulfonylurea class of drugs, an anti-diabetic that inhibits KATP channels in pancreatic β-cells, leading to increased insulin release. Sulfonylurea drugs work by inhibiting sulfonylurea receptor 1 (SUR1). In addition this drug acts as aTRPA1 agonist and demonstrates pleiotropic protective effects in acute CNS injury. Glibenclamide activates human TRPA1 in a concentration range that is commonly used to inhibit KATP channels in vitro. It has an EC50 value isof 48 nM at pH 7.4.
