Diclofenac (Voltaren) is a synthetic opener of KV7 channels with an effective concentration of 1-500 μM. The opening mechanism by Diclofenac is not fully understood and it is hypothesized that this is achieved by either destabilizing the closed channel conformation or stabilizing the channel in its open state. Diclofenac reduces evoked and spontaneous action potentials in neuronal cells. In addition, it also enhances M-currents and to exhibit anti-convulsing properties thus making it a possible drug template for the treatment of neuronal hyper excitability pathologies such as epilepsy, migraine or neuropathic pain. Diclofenac is also a non-steroidal anti-inflammatory drug preventing inflammation via the non-selective inhibition of the enzymes COX1 and COX2 and the reduction of Prostaglandin production
