GABA（A）Epsilon受体（胞外）抗体（50 ul）-Anti-GABA（A) Epsilon Receptor （extracellular)代理/参数/厂家-一抗-艾美捷科技有限公司

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背景资料: GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. Its production, release, reuptake, and metabolism all occur in the nervous system.nThe GABA transmitter interacts with two major types of receptors: ionotropic GABAA receptors (GABAAR) and metabotropic receptors (GABABR). GABAARs belong to the ligand-gated ion channel superfamily. GABA inhibits the activity of signal-receiving neurons by interacting with the GABAA receptor on these cells3. Binding of GABA to its GABAA receptor results in conformational changes that open a Cl- channel, producing an increase in membrane conductance that results in inhibition of neural activity.nGABAARs are heteropentamers, in which all five subunits contribute to the pore formation. To date, eight subunit isoforms have been cloned: α, β, γ, δ, ε, π, θ, and ρ1. Six α subunit isoforms have been found to exist in mammals (α1-α6). In most cases, native GABAA receptors consist of 2α, 2β, and 1γ subunits. The α subunit is the most common and is expressed ubiquitously. It determines the affinity of GABAARs for allosteric ligands.nEach subtype has a unique regional expression in the brain, and individual neurons often express multiple subtypes4. For example, the α4 subunit is detected in the hippocampus, cortex, olfactory bulb and in the basal forebrain

免疫原: GABA(A) Epsilon 受体 (胞外)抗体的免疫原肽段为(C)RLRYNDTFETLILH。此免疫原序列来源于131-144 位氨基酸残基，该序列来源于大鼠GABA(A) ε 受体 (Accession编号为Q9ES14)。胞外，N端。

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