TRPM7 (Transient Receptor Potential Cation Channel Subfamily M Member 7) is a Protein Coding gene. Among its related pathways are TRP channels and Cellular senescence (KEGG). TRPM7 belongs to the melastatin subfamily of transient receptor potential family of ion channels. The protein encoded by TRPM7 is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. The encoded protein is involved in cytoskeletal organization, cell adhesion, cell migration and organogenesis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. TRPM7 may also be associated with defects of cardiac function.
