SIX3 (SIX Homeobox 3) is a Protein Coding gene. Diseases associated with SIX3 include Schizencephaly and Holoprosencephaly 2. Among its related pathways are Circadian rythm related genes and Transcriptional Regulatory Network in Embryonic Stem Cell. GO annotations related to SIX3 include transcription factor activity, sequence-specific DNA binding and transcription coactivator activity. An important paralog of SIX3 is SIX6. SIX3 encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in SIX3 have been associated with holoprosencephaly type 2.
