Arachidonoyl-2’-fluoroethylamide （2-fluoro AEA） is an analog of anandamide in which the alcohol of the ethanolamide group has been removed and replaced with a fluorine atom. This substitution adds considerably increased binding affinity for the CB1 receptor. It also contributes additional selectivity， in that binding to CB2 is decreased relative to AEA. However， the in vivo activity of 2-fluoro AEA is enhanced much less than the binding affinity， because the analog remains a good substrate for FAAH and is rapidly hydrolyzed by this enzyme.
产品描述
An analog of AEA in which the alcohol of the ethanolamide group has been replaced with a fluorine atom， which increases the binding affinity and selectivity for the CB1 receptor； in vivo activity is enhanced much less than the binding affinity， because it is rapidly hydrolyzed by FAAH
