5-Aminosalicylic acid （5-ASA） is a metabolite and potential pharmacologically active component of sulphasalazine， a drug used in the treatment of Crohn’s disease and ulcerative colitis. However， the mechanism by which this drug works has not been established. In whole blood assays， 5-ASA proves to be a weak， non-selective inhibitor of both COX-1 and COX-2 with IC50 values of 410 and 61 uM， respectively. In ionophore-stimulated colonic mucosal cells， 1 mM 5-ASA does not inhibit prostaglandin E2 （PGE2） production， but does reduce leukotriene B4 （LTB4） synthesis approx. 50%. In ionophore-stimulated human leukocytes， 400 uM 5-ASA reduces LTB4 production approximately 20%. 5-ASA does not inhibit 15-hydroxy PGDH at concentrations up to 50 uM.
产品描述
5-ASA is a metabolite and potential pharmacologically active component of sulphasalazine， a drug used in the treatment of Crohn’s disease and ulcerative colitis. However， the mechanism by which this drug works has not been established. In whole blood assays， 5-ASA proves to be a weak， non-selective inhibitor of both COX-1 and COX-2 with IC50 values of 410 and 61 uM， respectively.{8427} In ionophore-stimulated colonic mucosal cells， 1 mM 5-ASA does not inhibit PGE2 production， but does reduce LTB4 synthesis approximately 50%.{8429} In ionophore-stimulated human leukocytes， 400 uM 5-ASA reduces LTB4 production approximately 20%.{8435} 5-ASA does not inhibit 15-hydroxy PGDH at concentrations up to 50 uM.{8455}
