Complexes containing Snf2h (SMARCA5) are capable of forming ordered nucleosome arrays on chromatin in vitro (may require intact histone H4 tails). SNF2h is also required for replication of pericentric heterochromatin in S-phase, specifically in conjunction with BAZ1A. Snf2h probably also plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Snf2h is a catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. Each complex contains subunits which may regulate the specificity or catalytic activity of SMARCA5. Snf2h possesses intrinsic ATP-dependent nucleosome remodelling activity. Anti-hSNF2H Antibody is ideal for research in Chromatin Remodeling, Epigenetics and Gene Expression.
应用类型
IF Microscopy,Immunoprecipitation,Western Blot,
免疫原
Anti-hSNF2H Antibody was produced in mice by repeated immunization with a recombinant protein of human SNF2H.
来源宿主
Mouse
反应性
H. sapiens (Human)
保存建议
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
