- 中文名称
【干冰】Anti-p19Arf (exon 2) (RAT) Monoclonal Antibody - 200-501-891
- 英文名字
- 【干冰】Anti-p19Arf (exon 2) (RAT) Monoclonal Antibody - 200-501-891
- 供应商
- Rockland
- 产品货号
- 200-501-891
- 产品报价
- ￥询价/100ug
- 产品说明书
- 点击查看
- 购买方式
- 90%产品中国有现货库存。银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- The Ink4a-Arf locus encodes two tumor suppressor proteins, p16Ink4a and p19Arf. Expression of Ink4a and Arf is regulated by distinct promoters upstream of alternative first exons whose products are spliced to a common second exon translated in alternative reading frames (from which Arf gets its name). The two genes are induced by different stress signals and can be separately mutated or silenced in tumor cells. Targeted disruption of either or both genes in mouse leads to spontaneous tumor formation, which is accelerated by exposure of the mutant animals to chemical carcinogens or ionizing radiation. Inactivation of ARF by mutation, deletion, or epigenetic silencing is observed in many human cancers, underscoring the role of this protein as a potent and ubiquitous tumor suppressor. p19Arf is activated by Myc or mutant Ras. Once activated, p19Arf binds to the p53 negative regulator Mdm2, leading to p53 stabilization and unleashing a p53-dependent transcriptional program that triggers either cell cycle arrest or apoptosis. p19Arf also has p53-independent inhibitory effects on cell proliferation. p19Arf is a nucleolar protein and is implicated in ribosomal biogenesis.
- 应用类型
- ELISA,IF Microscopy,Immunoprecipitation,Western Blot,
- 免疫原
- This protein G purified monoclonal antibody was produced by repeated immunizations with a synthetic peptide corresponding to an internal region near amino acid residues 54-75 of mouse p19Arf protein.
- 来源宿主
- Rat
- 反应性
- Cricetinae (Hamster); H. sapiens (Human); Mus musculus (Mouse)
- 保存建议
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
- 其他
- Rockland成立于1962年，是一家老牌抗体原产企业，其位于美国费城郊区的农场保有近20种实验动物。Rockland公司为生命科学领域提供丰富的、高质量的抗体，包括载脂蛋白、细胞周期/凋亡、细胞因子、细胞信号蛋白、酶类、细胞外基质、转录因子(NFkB)和泛素（Ubiquitin）等识别抗体，应用范围包括Western blot、免疫组化、免疫荧光和ELISA等。另外，Rockland也生产特别齐全的二抗，包括纯化、生物素、HRP/ALP、荧光标记二抗，应用十分广泛。
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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