A-366 is a potent, peptide-competitive inhibitor of the lysine methyltransferase G9a (IC50 = 3.3 nM) that displays greater than 1,000-fold selectivity over 21 other methyltransferases.{26028} A-366 significantly reduces the cellular levels of dimethylation on histone 3 at lysine 9 (H3K9Me2) in PC3 cells without reducing total histone 3, H3K27Me3, or H3K36Me2.{26028} See the Structural Genomics Consortium (SGC) website for more information.
产品描述
A potent, peptide-competitive inhibitor of the lysine methyltransferase G9a (IC50 = 3.3 nM); significantly reduces the cellular levels of dimethylation on histone 3 at lysine 9 (H3K9Me2) in PC3 cells without reducing total histone 3, H3K27Me3, or H3K36Me2
