Cathepsin D is a lysosomal aspartic protease of the pepsin family (1). Human cathepsin D is synthesized as a precursor protein, consisting of a signal peptide (aa 1-18), a propeptide (aa 19-64), and a mature chain (aa 65-412) ). The mature chain can be processed further to the light (aa 65-161) and heavy (aa 169-412) chains. It is expressed in most cells and overexpressed in breast cancer cells. It is a major enzyme in protein degradation in lysosomes, and also involved in the presentation of antigenic peptides. Mice deficient in this enzyme showed a progressive atrophy of the intestinal mucosa, a massive destruction of lymphoid organs, and a profound neuronal ceroid lipofucinosis, indicating that cathepsin D is essential for proteolysis of proteins regulating cell growth and tissue homeostasis. Cathepsin D secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogeneous inhibitor of angiogenesis.
应用类型
WB
免疫原
该Anti-Human Cathepsin D的详细信息查看ReliaTech提供的产品说明书。
来源宿主
该Anti-Human Cathepsin D的详细信息查看ReliaTech提供的产品说明书。
反应性
该Anti-Human Cathepsin D的详细信息查看ReliaTech提供的产品说明书。
保存建议
该Anti-Human Cathepsin D的详细信息查看ReliaTech提供的产品说明书。溶解建议：Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
