Cathepsin A/lyososomal carboxypeptidase A is a member of the serine carboxypeptidase family. Cathepsin A is a multifunctional enzyme that expresses deaminidase and esterase activities at neutral pH and carboxypeptidase activity at acidic pH. Also known as protective protein, its association with βgalactosidase (βgal) and neuraminidase is essential for βgal stability and neuraminidase activation in the lysosomes. Inherited deficiency of Cathepsin A causes the lysosomal storage disorder galactosialidosis, characterized by a combined secondary deficiency of βgal and neuraminidase. Cathepsin A is capable of hydrolyzing a variety of bioactive peptide hormones including tachykinins, indicating that extralysosomal Cathepsin A plays a role in regulation of functions of these molecules. Cathepsin A is synthesized as a singlechain precursor and processed into heavy (32 kDa) and light (20 kDa) chains, which are linked by disulfide bonds.
应用类型
WB
免疫原
该Anti-Human Cathepsin A的详细信息查看ReliaTech提供的产品说明书。
来源宿主
该Anti-Human Cathepsin A的详细信息查看ReliaTech提供的产品说明书。
反应性
该Anti-Human Cathepsin A的详细信息查看ReliaTech提供的产品说明书。
保存建议
该Anti-Human Cathepsin A的详细信息查看ReliaTech提供的产品说明书。溶解建议：Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
