CD106 / VCAM-1 (vascular cell adhesion molecule-1) is an Ig-like cell surface adhesion molecule binding VLA-4 integrin. VCAM-1 is a potent T cell costimulatory molecule taking part in their positive selection and survival, as well as in adhesion, transendothelial migration and activation of peripheral T cells. VCAM-1 is also involved in endothelial cell-cell contacts. Whereas VCAM-1 normally mediates leukocyte extravasion to sites of tissue inflammation, tumour cells can use overexpressed VCAM-1 to escape T cell immunity.
应用类型
FC (QC tested), IP, IHC(F), FUNC
免疫原
Murine preadipose cell line PA6
来源宿主
大鼠
反应性
Mouse
保存建议
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
