PCAF is a protein that shows homology to the yeast GCN5 and associates with p300/CBP. PCAF has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP (1). PCAF encodes a predicted 832-amino acid protein that showed by RNA blotting to be expressed in all tissues, most strongly in heart and skeletal muscle. PCAF has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. PCAF is required for MyoD activity and muscle differentiation. PCAF directly acetylated MyoD which then displays an increased affinity for its DNA target (2). PCAF Protein is ideal for investigators involved in Signaling Proteins, Acetyl/Methyltransferase Proteins, Cancer, Cell Cycle, and NfkB Pathway research.
序列
该【干冰】PCAF recombinant protein-GST fusion protein - 009-001-S81S的详细信息查看Rockland提供的产品说明书。
来源宿主
该【干冰】PCAF recombinant protein-GST fusion protein - 009-001-S81S的详细信息查看Rockland提供的产品说明书。
溶解建议
该【干冰】PCAF recombinant protein-GST fusion protein - 009-001-S81S的详细信息查看Rockland提供的产品说明书。
保存建议
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
