p18INK4C is a member of the INK4 family of proteins that regulate the G1 to S cell cycle transition by binding to and inhibiting the pRb kinase activity of cyclin-dependent kinases 4 and 6 (1). Mutation of p18INK4C impairs B-cell terminal differentiation and confers increased susceptibility to tumor development. p18INK4C can function as a tumor suppressor gene in Hodgkins lymphoma and its inactivation may contribute to the cell cycle deregulation and defective terminal differentiation characteristic of the Reed-Sternberg cells (2). p18INK4C Protein is ideal for investigators involved in Signaling Proteins, Cell Cycle Proteins, Cancer, and Cell Cycle research.
序列
该【干冰】p18INK4C recombinant protein-GST fusion protein - 009-001-S59S的详细信息查看Rockland提供的产品说明书。
来源宿主
该【干冰】p18INK4C recombinant protein-GST fusion protein - 009-001-S59S的详细信息查看Rockland提供的产品说明书。
溶解建议
该【干冰】p18INK4C recombinant protein-GST fusion protein - 009-001-S59S的详细信息查看Rockland提供的产品说明书。
保存建议
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
