IkB-beta is part of the NFkB complex and it inactivates NFkB complex by binding to it and trapping it in the cytoplasm. Phosphorylation of serine residues on IkBβ mediated by IkB kinases leads to its destruction via the ubiquitination pathway thereby allowing activation of the NFkB complex which translocates into the nucleus and binds DNA at kappa-B-binding motifs (1). The PEST domain of IkBβ can interact with two proteins KBRAS1 and KBRAS2 and this interaction can decrease the rate of degradation IkBβ. IkBβ has been shown to participate in multiple signaling pathways including adipocytokine signaling pathway, B-cell receptor signaling pathway, T-cell receptor signaling pathway and Hypoxia (2). IkBβ Protein is ideal for investigators involved in Signaling Proteins, Transcription Proteins, AKT/PKB Pathway, Apoptosis/Autophagy, Inflammation, and p38 Pathway research.
序列
该【干冰】I kappaB beta recombinant protein-GST fusion protein - 009-001-S19S的详细信息查看Rockland提供的产品说明书。
来源宿主
该【干冰】I kappaB beta recombinant protein-GST fusion protein - 009-001-S19S的详细信息查看Rockland提供的产品说明书。
溶解建议
该【干冰】I kappaB beta recombinant protein-GST fusion protein - 009-001-S19S的详细信息查看Rockland提供的产品说明书。
保存建议
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
