cAMP-NHS酯：第二信使探针构建的实用工具

环磷酸腺苷（cAMP）是细胞内信号诱导的第二信使，由ATP经G蛋白偶联的代谢型受体相关酶合成，受体激活后释放，参与糖原、糖及脂质代谢的调控。该cAMP-NHS酯是一种优良的构建模块，可用于开发cAMP探针与检测方法——NHS酯基团可与含伯氨基的分子偶联，便于将cAMP连接到载体蛋白、荧光标签或固相表面，为竞争性免疫检测与信号通路研究提供基础。

由艾美捷代理AAT Bioquest推出的cAMP-NHS酯（货号：17102），为固体粉末，分子量 684.64，可溶于 DMSO。NHS 酯基团可与蛋白、多肽上的伯氨基发生偶联反应，实现 cAMP 分子标记，助力构建 cAMP 示踪探针、免疫检测试剂。

储存上需低于 - 15℃冷冻保存，避光操作，收货后有效期 12 个月。在 GPCR 信号、糖脂代谢相关科研中，它是开发 cAMP 体外检测试剂盒、亲和探针的优质中间体，为解析 cAMP 信号网络、筛选信号通路调节剂提供有力工具。

文献引用

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