Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemocinfamily. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy.
序列
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该Recombinant Human Platelet Factor-4 (CXCL4) Variant-1 Protein的来源宿主请参考该产品的说明书
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该Recombinant Human Platelet Factor-4 (CXCL4) Variant-1 Protein的溶解建议请参考该产品的说明书
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