Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity).
序列
该HMGB3 Recombinant Protein的序列请参考该产品的说明书
来源宿主
E.coli
溶解建议
该HMGB3 Recombinant Protein的溶解建议请参考该产品的说明书
保存建议
该HMGB3 Recombinant Protein的保存建议请参考该产品的说明书
其他
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